Critical Reviews in Toxicology Vol 40, Special Supplements alert!

October to November 2010

Critical Reviews in Toxicology is pleased to announce that it is producing three special supplements with Volume 40.

Supplement 1 contains 3 open access review articles on the toxicology of Butadiene:
• 1, 3-Butadiene: I. Review of metabolism and the implications to human health risk assessment by C.R. Kirman et al.
• 1, 3-Butadiene: II. Genotoxicity profile by R. J. Albertini .
• 1, 3-Butadiene: III. Assessing carcinogenic modes of action by C.R. Kirman et al.
Supplement 2 reviews the current literature on Benzene and its leukemogenic effects by D. Galbraith et al.
Supplement 3 is an open access comprehensive review paper addressing endocrine disrupting activity by R. J. Witorsch and J. A. Thomas.

Will genomic technologies change the landscape of toxicology research?

With so many drug failures due to toxicity concerns, the development of more effective approaches to toxicity testing is of utmost importance. In their recent review “Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity,” Rusyn and Hege Harrill put forward the view that systems toxicology ‘offers the promise of more accurate predictions of adverse health effects in humans.’ They conclude that ‘Translational research bridging rodent and human toxicity will be the key to the success of this field.’ What will the impact of such approaches be on current gold standard? How widely used will they become?

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